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Nto the viral backbone (Table 1). Viral vaccine vector systems, such asNto the viral backbone (Table 1). Viral vaccine vector systems, such as adenovirus (type 2 and 5), adeno-associated virus, retrovirus, lentivirus, poxvirus, alphavirus, herpes simplex virus (HSV), offer several potential advantages over traditional vaccines, even though [23,24] each of them show some limitations and side
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Nto the viral backbone (Table 1). Viral vaccine vector systems, such asNto the viral backbone (Table 1). Viral vaccine vector systems, such as adenovirus (type 2 and 5), adeno-associated virus, retrovirus, lentivirus, poxvirus, alphavirus, herpes simplex virus (HSV), offer several potential advantages over traditional vaccines, even though [23,24] each of them show some limitations and side
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Nto the viral backbone (Table 1). Viral vaccine vector systems, such asNto the viral backbone (Table 1). Viral vaccine vector systems, such as adenovirus (type 2 and 5), adeno-associated virus, retrovirus, lentivirus, poxvirus, alphavirus, herpes simplex virus (HSV), offer several potential advantages over traditional vaccines, even though [23,24] each of them show some limitations and side
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Nto the viral backbone (Table 1). Viral vaccine vector systems, such asNto the viral backbone (Table 1). Viral vaccine vector systems, such as adenovirus (type 2 and 5), adeno-associated virus, retrovirus, lentivirus, poxvirus, alphavirus, herpes simplex virus (HSV), offer several potential advantages over traditional vaccines, even though [23,24] each of them show some limitations and side
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Nto the viral backbone (Table 1). Viral vaccine vector systems, such asNto the viral backbone (Table 1). Viral vaccine vector systems, such as adenovirus (type 2 and 5), adeno-associated virus, retrovirus, lentivirus, poxvirus, alphavirus, herpes simplex virus (HSV), offer several potential advantages over traditional vaccines, even though [23,24] each of them show some limitations and side
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Require further optimization. In addition to viral vectors, recombinant bacterial carriersRequire further optimization. In addition to viral vectors, recombinant bacterial carriers, derived from lactic acid bacteria, Salmonella and L. monocytogenes strains, have been used extensively as delivery systems being able to stimulate both systemic [29,30] and mucosal immune responses .GENE DELIVERY
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Vely been investigated as vaccine and drug delivery systems, adjuvants, nucleicVely been investigated as vaccine and drug delivery systems, adjuvants, nucleic acid delivery [31-34] platforms, and nanocarriers for imaging approaches . Nanoparticle systems can be designed to optimally present antigens in their native conformations to the immune system in controlled, slow release formulations p
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Taken into consideration , when using viral vectors for vaccination, including potentialTaken into consideration , when using viral vectors for vaccination, including potential integration, transcriptional activation of oncogenes, preexisting immunity against the viral vector and limitations , in transgenic capacity size. Several recombinant viral vectors, both RNA and DNA viruses, have been