In A-1 (Apo A-1) is a known negative acute phase protein and during infection in the WT mice its levels decreased by 166 . Among other actions, Apo A-1 neutralizes LPS and has anti-inflammatory activity [35,45]. The decrease in its levels as the duration of infection increases in WT mice (thereby lessening its anti-inflammatory influence), could be interpreted as permitting a vigorous defense agai