Ic cells have been shown to attenuate the immune response and promote tolerance in a way analogous to Tregulatory cells. DCs can also activate B-cells through costimulation of CD40, IL-6, and IL-12. The crux of DC interaction is in two places: DC maturation and T-cell synapse. Either point represents a potential target for dengue virus immune evasion. Should DCs fail to mature properly, they will